Rbm38 in cancer: role and mechanism
WebApr 8, 2024 · Extrachromosomal circular DNAs (eccDNAs) participate in tumorigenesis and tumor progression. However, the role and mechanism of eccDNAs have yet to be elucidated in non-small cell lung cancer (NSCLC). WebApr 7, 2024 · This mechanism is strongly related to inactivation of Rb1 by the HPV E7 protein [19,20]. Not all mechanisms associated with p16 expression are known in cancers. Although many studies have reported on the prognostic role of the decreased or increased p16 expression, the results are often conflicting .
Rbm38 in cancer: role and mechanism
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WebPeptidyl–prolyl isomerases (PPIase) facilitate the cis–trans interconversion of the peptidyl–prolyl bond and in such way affect protein folding. Pin1 is a PPIase, which specifically recognizes phosphorylated S/T-P bonds. The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARα) at position Ser 77.In the … WebAutophagy plays a complex role in tumor cells; studies have shown that autophagy can both inhibit cancer onset and promote advanced tumor growth. 4 Increasing evidence shows that cancer cells are more dependent on autophagy than normal cells, and this dependence may be further strengthened during the treatment process. 5 An increasing number of research …
WebMar 9, 2024 · Results report that RBM38 mediates direct inhibition of c-Myc expression, which in turn suppresses RBM38 expression. Thus, it can be concluded that RBM38 and c … WebRBM38 in cancer: role and mechanism Author: Cheng Zou, Ying Wan, Lingjing He, Jin Hai Zheng, Yang Mei, Junfeng Shi, Min Zhang, Zhiqiang Dong, Dingxiao Zhang Source: Cellular …
WebTo systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation. WebHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Recent studies reported that lncRNA LINC00473 (LNC473) was involved in cancer progression. However, the clinical significance and functional role of LNC473 in HCC progression is still unknown. In the present study, we found that the LNC473 expression ...
WebJul 8, 2024 · Here, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies …
WebAug 22, 2024 · Breast cancer is the most common malignancy in females worldwide (Chen et al, 2016; Siegel et al, 2016), and the metastasis accounts for the majority of deaths from breast cancer.One potential mechanism for invasion and metastasis in breast cancer is due to the occurring of epithelial–mesenchymal transition (EMT) that allows the polarised … images of michael bublelist of animals in maineWebApr 11, 2024 · Background Hypoxia-inducible factors (HIFs) are the most essential endogenous transcription factors in the hypoxic microenvironment and regulate multiple genes involved in the proliferation, migration, invasion, and EMT of hepatocellular carcinoma (HCC) cells. However, the regulatory mechanism of HIFs in driving HCC progression … images of michael biehnWebZou, C., Wan, Y., He, L., Zheng, J. H., Mei, Y., Shi, J., … Zhang, D. (2024). RBM38 in cancer: role and mechanism. Cellular and Molecular Life Sciences. doi:10.1007 ... images of michael fittWebNov 17, 2013 · SFN suppressed both COX-2 mRNA and protein levels by inhibiting NF-κB DNA-binding to the COX-2 promoter. It is known that COX-2 plays a role in cell proliferation, metastasis, and angiogenesis, and thus recent findings suggest that targeting COX-2 through p38 MAPK is a novel mechanism for cancer chemoprevention by SFN in human … images of michael ciminoWebCROSS-REFERENCE TO RELATED APPLICATIONS. This application is a Continuation of U.S. patent application Ser. No. 16/649,732, filed Mar. 23, 2024, which is a national stage filing u images of michael fanoneWebSep 1, 2012 · Abstract. The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and is a critical downstream target of the tumor suppressor pRB. The pRB/E2F pathway is defective in most human tumors, resulting in deregulated E2F activity that induces uncontrolled cell proliferation, a hallmark of tumor … list of animals in canada