Human silencing hub

Author: jzfs

August undefined, 2024

WebHere, we identify the epigenetic protein MPP8 as being essential for ground-state pluripotency. Its depletion leads to cell cycle arrest and spontaneous differentiation. MPP8 has been suggested to repress LINE1 elements by recruiting the human silencing hub (HUSH) complex to H3K9me3-rich regions. WebThe Human Silencing Hub (HUSH) complex epigenetically represses retroviruses, transposons and genes in vertebrates. HUSH therefore maintains genome integrity and is central in the interplay...

TASOR epigenetic repressor cooperates with a CNOT1 RNA

WebWhat I do: I am interested in how the human genome defends itself from invaders such as viruses and retrotransposons. I am investigating how the HUman Silencing Hub (HUSH) is able to distinguish foreign DNA from our own genes, and the mechanism of silencing. Research Interests: Intracellular immunity, epigenetics, transcription, molecular biology, … indicatif 482

The HUSH complex cooperates with TRIM28 to repress …

Web4 Nov 2024 · The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits the histone methyltransferase SETDB1 as well as Microrchidia CW-type zinc finger protein 2 (MORC2). Functional and mechanistic studies of the HUSH complex have hitherto been cente … WebGu, J., Ji, Z., Li, D., & Dong, Q. (2024). Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma. Web8 Apr 2024 · By integrating genetic studies with orthogonal approaches in AML cells, mice and humans, we established evidence that HUSH/MPP8 is dispensable for steady-state hematopoiesis but required for AML... lock off villa vs regular disney

The HUSH complex controls brain architecture and

Periphilin self-association underpins epigenetic silencing …

WebHis discovery of the 'HUSH' (Human Silencing Hub) epigenetic silencing complex explains how the genome distinguishes newly integrated genetic material from endogenous genes through recognition of intronless DNA. This work uncovered an unanticipated, innate immune surveillance system that discriminates 'self' from 'non-self' genomic DNA and ... Web4 Nov 2024 · The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits the histone methyltransferase … indicatif +33Web1 Apr 2024 · Human silencing hub (HUSH) – a complex of transcription activation suppressor (TASOR), M-phase phosphoprotein 8 (MPP8), and periphilin – is an … lock-off unit

"Web13 Feb 2024 · February 13, 2024 The crystal structure of MORC2, an effector of epigenetic silencing by the human silencing hub (HUSH). MORC2 forms ATP-dependent dimers … " - Human silencing hub

Human silencing hub

Web8 Apr 2024 · We identified MPHOSPH8/MPP8, a component of the human silencing hub (HUSH) complex, as an acute myeloid leukemia (AML)-selective dependency by … Web12 Feb 2024 · Today, two studies highlight Human Silencing Hub (HUSH) as a potential restriction factor that controls viral expression and is antagonized by Vpx. This Review …

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The human silencing hub (HUSH) complex was discovered as a novel epigenetic complex responsible for position-effect variegation of integrated transgenes in human cells 25. It is associated with... WebThe Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transgenes. HUSH recruits effectors that alter the epigenetic landscape and chromatin structure, but how HUSH recognizes target loci and represses their expression remains unclear.

Web1 Apr 2016 · The recent identification of the HUSH (Human Silencing Hub) complex suggests that more recent evolutionary developments contribute to the mechanisms underlying PEV in human cells. Although HUSH‐mediated repression also involves heterochromatin spreading through the reading and writing of the repressive H3K9me3 … Web9 Oct 2024 · The Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transgenes. HUSH recruits …

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Web10 Jan 2024 · The Human Silencing Hub (HUSH) complex—formed by TASOR (alias C3orf63, FAM208A), MPP8, and PPHLN-1—was identified as a potential player in HIV …

Web5 Sep 2006 · Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 … indicatif 480WebBiological function Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and … indicatif 327Web30 Nov 2024 · Here we show that the HUSH (human silencing hub) complex containing H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and Microrchidia CW-type … indicatif +491Web26 Jun 2015 · A nonlethal forward genetic screen in near-haploid KBM7 cells identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, … indicatif 410Web12 May 2024 · In summary, Gu et al. identified an AML-selective dependency, MPP8, and demonstrated that epigenetic silencing of L1 retrotransposons by HUSH/MPP8 is critical for the propagation of AML. L1 retrotransposons are commonly recognized by their cancer-promoting roles as important sources of oncogene activation. indicatif 5966WebFunction Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing ( PubMed: 28581500, PubMed: 29440755, PubMed: 32693025 ). lock-off unitsWeb3 Nov 2024 · The results suggest that LINE-1s may drive physiological or autoinflammatory responses through dsRNA sensing and gene-regulatory roles and are controlled by the HUSH complex. The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and … lock off unit