Cisplatin ic50
WebDrug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Cisplatin Drug Target: DNA crosslinker Drug Target … STR profiles of cell lines Cell line authentication. Concerns around the … The IC50 and AUC are estimated using a non-linear mixed effect model fitting a … Users have a non-exclusive, non-transferable right to use data files for … WebFeb 5, 2016 · Cisplatin remains to be primary chemotherapeutic drug for gastric cancer patients, especially for advanced stage ones. However, primary or acquired resistance …
Cisplatin ic50
Did you know?
WebThe IC50 values of the two platinum derivatives varied considerably. The values for cisplatin varied between 0.022 microgram ml-1 and 0.56 microgram ml-1 and the … WebOverexpressing miR-515-5p markedly reduced cisplatin and 5-Fu IC50 values in HK-1/CDDP and CNE-1/CDDP cells, while IL-25 transfection was sufficient to reverse this phenotype (Figure 4E and F). As such, our data demonstrate that circNRIP1 enhances 5-Fu and cisplatin resistance in NPC cells at least in part via sequestering miR-515-5p and ...
WebOct 25, 2016 · To overcome severe MTT artifacts, we developed an unbiased direct IC50 measurement method, the limiting dilution assay. This detection technique led us to the … WebIC50 values were calculated. Evaluation of apoptosis and DNA damage were performed. In addition, the expression of pro-apoptotic and anti-apoptotic genes and proteins were tested. IC50 values indicated less toxicity of the Schiff base …
WebDownload scientific diagram Summary of IC50 values of sinomenine or cisplatin in gastric cancer cells. from publication: Sinomenine sensitizes human gastric cancer cells to … WebJun 1, 2024 · The cisplatin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 60 μmol/L to 40 μmol/L and from 40 μmol/L to 20 μmol/L, respectively. Similarly, the doxorubicin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 15 μmol/L to 7.5 μmol/L and 5 μmol/L to 3 μmol/L, respectively.
WebIC50 cisplatin concentration (mM) Source publication Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple …
WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ctrl+alt+del webcomic charactersWebJun 5, 2024 · We first analyzed the correlation between TFEB expression and half maximal inhibitory concentration (IC50) of CDDP using Genomics of Drug Sensitivity in Cancer … ctrl alt del tabletop webcomicWebApr 10, 2024 · The half-maximal inhibitory concentration values (IC 50) were calculated by interpolation from the nonlinear regression curves obtained from cell proliferation/cytotoxicity data using “log (inhibitor) versus the normalized response–variable slope equation”. A p -value lower than 0.05 was considered statistically significant. 3. Results earth transparent cartoonWebThe SIN mean IC50 for HGC-27, SGC-7901, and BGC-803 at 24 hours was 372.60, 284.40, and 279.70 μM; The cisplatin mean IC50 for HGC-27, SGC-7901, and BGC-803 at 24 hours was 3.85, 3.13, and... ctrl alt del spanish keyboardWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … earth traitsWebPurpose: Alterations in the DNA mismatch repair (MMR) proteins have been associated with an increased resistance of many cancer cell lines to cisplatin. The aim of this work was … earth transparent clipartWebThe DDP at a concentration of IC50 (AGS/DDP cells, 71.34 μM; MKN45/DDP cells, 61.28 μM) was used for further experiments. Bax and Bcl-2 are biomarkers of apoptosis. As illustrated in Figure 2E , the protein expression of Bax was remarkably elevated, while Bcl-2 was declined in AGS/DDP and MKN45/DDP cells following sh-HCG11 transfection or … ctrl alt del mac windows keyboard